diff --git a/erpnext/stock/doctype/item/item.py b/erpnext/stock/doctype/item/item.py
index a707a0a4bc3..d6ec2a4f417 100644
--- a/erpnext/stock/doctype/item/item.py
+++ b/erpnext/stock/doctype/item/item.py
@@ -7,6 +7,7 @@ import json
 import frappe
 from frappe import _, bold
 from frappe.model.document import Document
+from frappe.model.naming import NamingSeries
 from frappe.query_builder import Interval
 from frappe.query_builder.functions import Count, CurDate, UnixTimestamp
 from frappe.utils import (
@@ -409,6 +410,24 @@ class Item(Document):
 					)
 				)
 
+			if self.is_new() and series:
+				obj = NamingSeries(series)
+				prefix = obj.get_prefix()
+				doctype = frappe.qb.DocType("Series")
+
+				query = frappe.qb.from_(doctype).select(doctype.name).where(doctype.name.like(f"{prefix}%"))
+
+				prefix_exists = query.run(as_dict=True)
+				if prefix_exists:
+					frappe.msgprint(
+						_(
+							"The {0} prefix '{1}' already exists. Please change the Serial No Series, otherwise you will get a Duplicate Entry error."
+						).format(bold(frappe.unscrub(field)), bold(prefix)),
+						title=_("Serial No Series Overlap"),
+						indicator="yellow",
+						alert=True,
+					)
+
 	def check_for_active_boms(self):
 		if self.default_bom:
 			bom_item = frappe.db.get_value("BOM", self.default_bom, "item")
diff --git a/erpnext/stock/serial_batch_bundle.py b/erpnext/stock/serial_batch_bundle.py
index 208f9c048a0..298cec2fa89 100644
--- a/erpnext/stock/serial_batch_bundle.py
+++ b/erpnext/stock/serial_batch_bundle.py
@@ -1432,7 +1432,18 @@ class SerialBatchCreation:
 				"batch_no",
 			]
 
-			frappe.db.bulk_insert("Serial No", fields=fields, values=set(serial_nos_details))
+			try:
+				frappe.db.bulk_insert("Serial No", fields=fields, values=set(serial_nos_details))
+			except Exception as e:
+				if e and len(e.args) > 1 and "Duplicate" in e.args[1]:
+					frappe.throw(
+						_(
+							"A naming series conflict occurred while creating serial numbers. Please change the naming series for the item {0}."
+						).format(bold(self.item_code)),
+						title=_("Duplicate Serial Number Error"),
+					)
+				else:
+					raise e
 
 		obj.update_counter(current_value)