diff --git a/erpnext/stock/doctype/item/item.py b/erpnext/stock/doctype/item/item.py
index f32e9599039..17cf044074d 100644
--- a/erpnext/stock/doctype/item/item.py
+++ b/erpnext/stock/doctype/item/item.py
@@ -122,6 +122,7 @@ class Item(WebsiteGenerator):
 		self.validate_fixed_asset()
 		self.validate_retain_sample()
 		self.validate_uom_conversion_factor()
+		self.validate_item_defaults()
 		self.update_defaults_from_item_group()
 
 		if not self.get("__islocal"):
@@ -663,6 +664,12 @@ class Item(WebsiteGenerator):
 					template_item.flags.ignore_permissions = True
 					template_item.save()
 
+	def validate_item_defaults(self):
+		companies = list(set([row.company for row in self.item_defaults]))
+
+		if len(companies) != len(self.item_defaults):
+			frappe.throw(_("Cannot set multiple Item Defaults for a company."))
+
 	def update_defaults_from_item_group(self):
 		"""Get defaults from Item Group"""
 		if self.item_group and not self.item_defaults: