diff --git a/erpnext/controllers/item_variant.py b/erpnext/controllers/item_variant.py
index 0ba090956ca..74b7dfb5c24 100644
--- a/erpnext/controllers/item_variant.py
+++ b/erpnext/controllers/item_variant.py
@@ -209,7 +209,9 @@ def create_variant(item, args, use_template_image=False):
 	variant_attributes = []
 
 	for d in template.attributes:
-		variant_attributes.append({"attribute": d.attribute, "attribute_value": args.get(d.attribute)})
+		attribute_value = args.get(_(d.attribute)) or args.get(d.attribute)
+		if attribute_value:
+			variant_attributes.append({"attribute": d.attribute, "attribute_value": attribute_value})
 
 	variant.set("attributes", variant_attributes)
 	copy_attributes_to_variant(template, variant)
@@ -228,6 +230,12 @@ def enqueue_multiple_variant_creation(item, args, use_template_image=False):
 	# There can be innumerable attribute combinations, enqueue
 	if isinstance(args, str):
 		variants = json.loads(args)
+	else:
+		variants = args
+	variants = {key: values for key, values in variants.items() if values}
+	if not variants:
+		frappe.throw(_("Please select at least one attribute value"))
+
 	total_variants = 1
 	for key in variants:
 		total_variants *= len(variants[key])
@@ -251,6 +259,7 @@ def create_multiple_variants(item, args, use_template_image=False):
 	count = 0
 	if isinstance(args, str):
 		args = json.loads(args)
+	args = {key: values for key, values in args.items() if values}
 
 	template_item = frappe.get_doc("Item", item)
 	args_set = generate_keyed_value_combinations(args)
@@ -285,6 +294,9 @@ def generate_keyed_value_combinations(args):
 
 	"""
 	# Return empty list if empty
+	if not args:
+		return []
+	args = {key: values for key, values in args.items() if values}
 	if not args:
 		return []
 
diff --git a/erpnext/controllers/tests/test_item_variant.py b/erpnext/controllers/tests/test_item_variant.py
index 68c8d2cd2c3..eacefbb2806 100644
--- a/erpnext/controllers/tests/test_item_variant.py
+++ b/erpnext/controllers/tests/test_item_variant.py
@@ -3,7 +3,11 @@ import unittest
 
 import frappe
 
-from erpnext.controllers.item_variant import copy_attributes_to_variant, make_variant_item_code
+from erpnext.controllers.item_variant import (
+	copy_attributes_to_variant,
+	generate_keyed_value_combinations,
+	make_variant_item_code,
+)
 from erpnext.stock.doctype.item.test_item import set_item_variant_settings
 from erpnext.stock.doctype.quality_inspection.test_quality_inspection import (
 	create_quality_inspection_parameter,
@@ -17,6 +21,19 @@ class TestItemVariant(unittest.TestCase):
 		variant = make_item_variant()
 		self.assertEqual(variant.get("quality_inspection_template"), "_Test QC Template")
 
+	def test_generate_keyed_value_combinations_ignores_empty_attributes(self):
+		combinations = generate_keyed_value_combinations(
+			{"Test Colour": ["Red", "Blue"], "Test Size": ["Small", "Large"], "Test Fit": []}
+		)
+
+		self.assertEqual(len(combinations), 4)
+		self.assertNotIn("Test Fit", combinations[0])
+
+		single_attribute_combinations = generate_keyed_value_combinations(
+			{"Test Colour": ["Red", "Blue"], "Test Size": []}
+		)
+		self.assertEqual(single_attribute_combinations, [{"Test Colour": "Red"}, {"Test Colour": "Blue"}])
+
 
 def create_variant_with_tables(item, args):
 	if isinstance(args, str):
diff --git a/erpnext/stock/doctype/item/item.js b/erpnext/stock/doctype/item/item.js
index 5bf0d54ee26..19585b9dabc 100644
--- a/erpnext/stock/doctype/item/item.js
+++ b/erpnext/stock/doctype/item/item.js
@@ -581,11 +581,10 @@ $.extend(erpnext.item, {
 						default: 0,
 						onchange: function () {
 							let selected_attributes = get_selected_attributes();
-							let lengths = [];
-							Object.keys(selected_attributes).map((key) => {
-								lengths.push(selected_attributes[key].length);
+							let lengths = Object.keys(selected_attributes).map((key) => {
+								return selected_attributes[key].length;
 							});
-							if (lengths.includes(0)) {
+							if (!lengths.length) {
 								me.multiple_variant_dialog.get_primary_btn().html(__("Create Variants"));
 								me.multiple_variant_dialog.disable_primary_action();
 							} else {
@@ -622,7 +621,7 @@ $.extend(erpnext.item, {
 						fieldtype: "HTML",
 						fieldname: "help",
 						options: `<label class="control-label">
-							${__("Select at least one value from each of the attributes.")}
+							${__("Select at least one attribute value.")}
 						</label>`,
 					},
 				]
@@ -680,6 +679,9 @@ $.extend(erpnext.item, {
 						selected_attributes[attribute_name].push($(opt).attr("data-fieldname"));
 					}
 				});
+				if (!selected_attributes[attribute_name].length) {
+					delete selected_attributes[attribute_name];
+				}
 			});
 
 			return selected_attributes;
diff --git a/erpnext/stock/doctype/item/item.py b/erpnext/stock/doctype/item/item.py
index b011dcf8fcd..05e8a2f3779 100644
--- a/erpnext/stock/doctype/item/item.py
+++ b/erpnext/stock/doctype/item/item.py
@@ -855,8 +855,13 @@ class Item(Document):
 					if disabled:
 						frappe.throw(_("Attribute {0} is disabled.").format(frappe.bold(d.attribute)))
 
-					if not numeric_values and not frappe.db.exists(
-						"Item Attribute Value", {"parent": d.attribute, "attribute_value": d.attribute_value}
+					if (
+						not numeric_values
+						and d.attribute_value
+						and not frappe.db.exists(
+							"Item Attribute Value",
+							{"parent": d.attribute, "attribute_value": d.attribute_value},
+						)
 					):
 						frappe.throw(
 							_("Attribute Value {0} is not valid for the selected attribute {1}.").format(