diff --git a/erpnext/stock/doctype/material_request/material_request.js b/erpnext/stock/doctype/material_request/material_request.js
index 7dab81beba1..4ff2c2c27af 100644
--- a/erpnext/stock/doctype/material_request/material_request.js
+++ b/erpnext/stock/doctype/material_request/material_request.js
@@ -411,13 +411,187 @@ frappe.ui.form.on("Material Request", {
 	},
 
 	make_purchase_order: function (frm) {
-		frappe.model.open_mapped_doc({
-			method: "erpnext.stock.doctype.material_request.material_request.make_purchase_order",
-			frm: frm,
-			run_link_triggers: true,
+		frappe.call({
+			method: "erpnext.stock.doctype.material_request.material_request.get_item_default_suppliers",
+			args: {
+				source_name: frm.doc.name,
+				filtered_children: (frm.get_selected() || {}).items || [],
+			},
+			freeze: true,
+			callback: function (r) {
+				const items = r.message || [];
+				const suppliers = new Set(items.map((item) => item.supplier || ""));
+
+				if (suppliers.size > 1) {
+					frm.events.select_suppliers_for_items(frm, items);
+					return;
+				}
+
+				frappe.model.open_mapped_doc({
+					method: "erpnext.stock.doctype.material_request.material_request.make_purchase_order",
+					frm: frm,
+					args: { supplier: items.length ? items[0].supplier : null },
+					run_link_triggers: true,
+				});
+			},
 		});
 	},
 
+	select_suppliers_for_items: function (frm, items) {
+		const rows = items.map((item) => Object.assign({}, item, { qty: item.pending_qty, __checked: 1 }));
+
+		const supplier_query = () => {
+			return { filters: { disabled: 0, prevent_pos: 0 } };
+		};
+
+		const dialog = new frappe.ui.Dialog({
+			title: __("Select Supplier for Items"),
+			size: "large",
+			fields: [
+				{
+					fieldname: "supplier",
+					fieldtype: "Link",
+					options: "Supplier",
+					label: __("Set Supplier for All Items"),
+					get_query: supplier_query,
+					onchange: function () {
+						const supplier = dialog.get_value("supplier");
+						if (!supplier) return;
+
+						rows.forEach((row) => (row.supplier = supplier));
+						dialog.fields_dict.items.grid.refresh();
+					},
+				},
+				{ fieldtype: "Column Break" },
+				{ fieldtype: "Section Break" },
+				{
+					fieldname: "items",
+					fieldtype: "Table",
+					label: __("Items"),
+					cannot_add_rows: true,
+					cannot_delete_rows: true,
+					in_place_edit: true,
+					data: rows,
+					get_data: () => rows,
+					description: __("A separate Purchase Order is created for each Supplier."),
+					fields: [
+						{
+							fieldtype: "Data",
+							fieldname: "material_request_item",
+							hidden: 1,
+						},
+						{
+							fieldtype: "Link",
+							fieldname: "item_code",
+							options: "Item",
+							label: __("Item Code"),
+							read_only: 1,
+							in_list_view: 1,
+							columns: 3,
+						},
+						{
+							fieldtype: "Data",
+							fieldname: "item_name",
+							label: __("Item Name"),
+							read_only: 1,
+							in_list_view: 1,
+							columns: 2,
+						},
+						{
+							fieldtype: "Float",
+							fieldname: "pending_qty",
+							hidden: 1,
+						},
+						{
+							fieldtype: "Float",
+							fieldname: "qty",
+							label: __("Quantity"),
+							reqd: 1,
+							in_list_view: 1,
+							columns: 1,
+						},
+						{
+							fieldtype: "Link",
+							fieldname: "uom",
+							options: "UOM",
+							label: __("UOM"),
+							read_only: 1,
+							in_list_view: 1,
+							columns: 1,
+						},
+						{
+							fieldtype: "Link",
+							fieldname: "supplier",
+							options: "Supplier",
+							label: __("Supplier"),
+							get_query: supplier_query,
+							reqd: 1,
+							in_list_view: 1,
+							columns: 3,
+						},
+					],
+				},
+			],
+			primary_action_label: __("Create"),
+			primary_action: async function (values) {
+				const item_suppliers = (values.items || []).filter((row) => row.__checked);
+				if (!item_suppliers.length) {
+					frappe.throw(__("Select at least one Item"));
+				}
+
+				const item_link = (row) =>
+					frappe.utils.get_form_link(
+						"Item",
+						row.item_code,
+						true,
+						frappe.utils.escape_html(row.item_code)
+					);
+
+				const missing_supplier = item_suppliers.find((row) => !row.supplier);
+				if (missing_supplier) {
+					frappe.throw(__("Select a Supplier for Item {0}", [item_link(missing_supplier)]));
+				}
+
+				const invalid_qty = item_suppliers.find(
+					(row) => flt(row.qty) <= 0 || flt(row.qty) > flt(row.pending_qty)
+				);
+				if (invalid_qty) {
+					const pending_qty = `${format_number(invalid_qty.pending_qty)} ${frappe.utils.escape_html(
+						invalid_qty.uom
+					)}`;
+					frappe.throw(
+						__("Quantity for Item {0} must be greater than zero and cannot exceed {1}", [
+							item_link(invalid_qty),
+							`<b>${pending_qty}</b>`,
+						])
+					);
+				}
+
+				if (!(await erpnext.utils.confirm_if_drafts_exist(frm.doc, "Purchase Order"))) {
+					return;
+				}
+
+				frappe.call({
+					method: "erpnext.stock.doctype.material_request.material_request.make_purchase_orders_by_supplier",
+					args: { source_name: frm.doc.name, item_suppliers: item_suppliers },
+					freeze: true,
+					callback: function (r) {
+						if (r.exc) return;
+
+						dialog.hide();
+
+						const purchase_orders = r.message || [];
+						if (purchase_orders.length === 1) {
+							frappe.set_route("Form", "Purchase Order", purchase_orders[0]);
+						}
+					},
+				});
+			},
+		});
+
+		dialog.show();
+	},
+
 	make_request_for_quotation: function (frm) {
 		frappe.model.open_mapped_doc({
 			method: "erpnext.stock.doctype.material_request.material_request.make_request_for_quotation",
diff --git a/erpnext/stock/doctype/material_request/material_request.py b/erpnext/stock/doctype/material_request/material_request.py
index daebeaa4e1b..431bdd742a0 100644
--- a/erpnext/stock/doctype/material_request/material_request.py
+++ b/erpnext/stock/doctype/material_request/material_request.py
@@ -13,12 +13,24 @@ from frappe import _, msgprint
 from frappe.model.mapper import get_mapped_doc
 from frappe.query_builder import Order
 from frappe.query_builder.functions import Sum
-from frappe.utils import cint, cstr, flt, get_link_to_form, getdate, new_line_sep, nowdate
+from frappe.utils import (
+	cint,
+	comma_and,
+	cstr,
+	flt,
+	get_link_to_form,
+	getdate,
+	new_line_sep,
+	nowdate,
+)
 
 from erpnext.buying.utils import check_on_hold_or_closed_status, validate_for_items
 from erpnext.controllers.buying_controller import BuyingController
 from erpnext.manufacturing.doctype.work_order.work_order import get_item_details
-from erpnext.stock.get_item_details import get_price_list_rate_for
+from erpnext.setup.doctype.brand.brand import get_brand_defaults
+from erpnext.setup.doctype.item_group.item_group import get_item_group_defaults
+from erpnext.stock.doctype.item.item import get_item_defaults
+from erpnext.stock.get_item_details import get_default_supplier, get_price_list_rate_for
 from erpnext.stock.stock_balance import get_indented_qty, update_bin_qty
 from erpnext.subcontracting.doctype.subcontracting_bom.subcontracting_bom import (
 	get_subcontracting_boms_for_finished_goods,
@@ -485,6 +497,16 @@ def set_missing_values(source, target_doc):
 	target_doc.run_method("calculate_taxes_and_totals")
 
 
+def get_source_item_for_qty(item, qty):
+	"""Copy of the source row whose pending quantity is the requested quantity."""
+	source_item = frappe._dict(item.as_dict())
+	source_item.ordered_qty = 0
+	source_item.received_qty = 0
+	source_item.stock_qty = flt(qty) * flt(item.conversion_factor)
+
+	return source_item
+
+
 def update_item(obj, target, source_parent):
 	target.conversion_factor = obj.conversion_factor
 
@@ -538,7 +560,7 @@ def update_status(name, status):
 @frappe.whitelist()
 def make_purchase_order(source_name, target_doc=None, args=None):
 	if args is None:
-		args = {}
+		args = frappe.flags.args or {}
 	if isinstance(args, str):
 		args = json.loads(args)
 
@@ -546,10 +568,19 @@ def make_purchase_order(source_name, target_doc=None, args=None):
 		frappe.db.get_value("Material Request", source_name, "material_request_type") == "Subcontracting"
 	)
 
+	requested_qty = args.get("requested_qty") or {}
+
 	def postprocess(source, target_doc):
 		target_doc.is_subcontracted = is_subcontracted
+		if args.get("supplier"):
+			target_doc.supplier = args.get("supplier")
 		set_missing_values(source, target_doc)
 
+	def update_requested_item(obj, target, source_parent):
+		if obj.name in requested_qty:
+			obj = get_source_item_for_qty(obj, requested_qty[obj.name])
+		update_item(obj, target, source_parent)
+
 	def select_item(d):
 		filtered_items = args.get("filtered_children", [])
 		child_filter = d.name in filtered_items if filtered_items else True
@@ -589,7 +620,7 @@ def make_purchase_order(source_name, target_doc=None, args=None):
 				"doctype": "Purchase Order Item",
 				"field_map": generate_field_map(),
 				"field_no_map": ["item_code", "item_name", "qty"] if is_subcontracted else [],
-				"postprocess": update_item,
+				"postprocess": update_requested_item,
 				"condition": select_item,
 			},
 		},
@@ -601,6 +632,119 @@ def make_purchase_order(source_name, target_doc=None, args=None):
 	return doclist
 
 
+def get_default_supplier_for_item(item_code: str, company: str) -> str | None:
+	return get_default_supplier(
+		frappe._dict(),
+		get_item_defaults(item_code, company),
+		get_item_group_defaults(item_code, company),
+		get_brand_defaults(item_code, company),
+	)
+
+
+@frappe.whitelist()
+def get_item_default_suppliers(source_name: str, filtered_children: str | list | None = None) -> list[dict]:
+	"""Pending items of the Material Request with their default supplier."""
+	filtered_children = frappe.parse_json(filtered_children) if filtered_children else []
+
+	material_request = frappe.get_doc("Material Request", source_name)
+	material_request.check_permission("read")
+
+	items = []
+	for item in material_request.items:
+		if filtered_children and item.name not in filtered_children:
+			continue
+
+		ordered_qty = flt(item.ordered_qty) or flt(item.received_qty)
+		if ordered_qty >= flt(item.stock_qty):
+			continue
+
+		items.append(
+			{
+				"material_request_item": item.name,
+				"item_code": item.item_code,
+				"item_name": item.item_name,
+				"pending_qty": (flt(item.stock_qty) - ordered_qty) / (flt(item.conversion_factor) or 1),
+				"uom": item.uom,
+				"supplier": get_default_supplier_for_item(item.item_code, material_request.company),
+			}
+		)
+
+	return items
+
+
+@frappe.whitelist(methods=["POST"])
+def make_purchase_orders_by_supplier(source_name: str, item_suppliers: str | list) -> list[str]:
+	"""Create one draft Purchase Order per supplier for the given Material Request items."""
+	item_suppliers = frappe.parse_json(item_suppliers)
+	if not item_suppliers:
+		frappe.throw(_("Select at least one Item"))
+
+	pending_items = {
+		d["material_request_item"]: frappe._dict(d) for d in get_item_default_suppliers(source_name)
+	}
+
+	items_by_supplier = {}
+	requested_items = set()
+	for row in item_suppliers:
+		row = frappe._dict(row)
+		pending = pending_items.get(row.material_request_item) or frappe._dict()
+		item_link = get_link_to_form("Item", row.item_code)
+
+		if row.material_request_item in requested_items:
+			frappe.throw(_("Item {0} cannot be ordered more than once").format(item_link))
+
+		requested_items.add(row.material_request_item)
+
+		if not row.supplier:
+			frappe.throw(_("Select a Supplier for Item {0}").format(item_link))
+
+		if flt(row.qty) <= 0 or flt(row.qty) > flt(pending.pending_qty):
+			pending_qty = frappe.format_value(flt(pending.pending_qty), "Float")
+			frappe.throw(
+				_("Quantity for Item {0} must be greater than zero and cannot exceed {1}").format(
+					item_link, frappe.bold(f"{pending_qty} {pending.uom or ''}".strip())
+				)
+			)
+
+		items_by_supplier.setdefault(row.supplier, {})[row.material_request_item] = flt(row.qty)
+
+	purchase_orders = []
+	is_rescheduled = False
+	for supplier, requested_qty in items_by_supplier.items():
+		purchase_order = make_purchase_order(
+			source_name,
+			args={
+				"supplier": supplier,
+				"filtered_children": list(requested_qty),
+				"requested_qty": requested_qty,
+			},
+		)
+		for item in purchase_order.items:
+			if not item.schedule_date:
+				item.schedule_date = nowdate()
+				is_rescheduled = True
+
+		purchase_order.insert()
+		purchase_orders.append(purchase_order.name)
+
+	if is_rescheduled:
+		frappe.toast(
+			_("{0} was set to today for items whose requested date has passed").format(
+				_(frappe.get_meta("Purchase Order Item").get_label("schedule_date"))
+			),
+			indicator="orange",
+		)
+
+	if len(purchase_orders) > 1:
+		frappe.msgprint(
+			_("{0} created").format(
+				comma_and([get_link_to_form("Purchase Order", name) for name in purchase_orders])
+			)
+		)
+
+	return purchase_orders
+
+
 @frappe.whitelist()
 def make_request_for_quotation(source_name, target_doc=None):
 	doclist = get_mapped_doc(
diff --git a/erpnext/stock/doctype/material_request/test_material_request.py b/erpnext/stock/doctype/material_request/test_material_request.py
index 51ad01517a4..7d044b929f4 100644
--- a/erpnext/stock/doctype/material_request/test_material_request.py
+++ b/erpnext/stock/doctype/material_request/test_material_request.py
@@ -6,7 +6,7 @@
 
 
 import frappe
-from frappe.utils import flt, today
+from frappe.utils import add_days, flt, getdate, today
 
 from erpnext.controllers.accounts_controller import InvalidQtyError
 from erpnext.stock.doctype.item.test_item import create_item
@@ -1211,6 +1211,144 @@ class TestMaterialRequest(ERPNextTestSuite):
 		self.assertEqual(material_request.status, "Transferred")
 		self.assertEqual(material_request.transfer_status, "Completed")
 
+	def test_get_item_default_suppliers(self):
+		from erpnext.stock.doctype.material_request.material_request import get_item_default_suppliers
+
+		with_supplier = create_item_with_default_supplier("_Test MR Item Supplier A", "_Test Supplier")
+		without_supplier = create_item("_Test MR Item Without Supplier").name
+
+		mr = make_material_request_for_items([with_supplier, without_supplier])
+		items = get_item_default_suppliers(mr.name)
+
+		self.assertEqual([d["item_code"] for d in items], [with_supplier, without_supplier])
+		self.assertEqual(items[0]["supplier"], "_Test Supplier")
+		self.assertFalse(items[1]["supplier"])
+		self.assertEqual(items[0]["pending_qty"], 10)
+
+	def test_make_purchase_order_sets_supplier(self):
+		mr = make_material_request_for_items(["_Test Item"])
+		po = make_purchase_order(mr.name, args={"supplier": "_Test Supplier"})
+
+		self.assertEqual(po.supplier, "_Test Supplier")
+
+	def test_make_purchase_orders_by_supplier(self):
+		from erpnext.stock.doctype.material_request.material_request import make_purchase_orders_by_supplier
+
+		item_codes = [create_item(f"_Test MR Grouped Item {index}").name for index in range(1, 4)]
+		mr = make_material_request_for_items(item_codes)
+		suppliers = ["_Test Supplier", "_Test Supplier", "_Test Supplier 1"]
+
+		purchase_orders = make_purchase_orders_by_supplier(
+			mr.name,
+			[
+				{
+					"material_request_item": item.name,
+					"item_code": item.item_code,
+					"qty": qty,
+					"supplier": supplier,
+				}
+				for item, supplier, qty in zip(mr.items, suppliers, [10, 10, 4], strict=True)
+			],
+		)
+
+		self.assertEqual(len(purchase_orders), 2)
+
+		first, second = (frappe.get_doc("Purchase Order", name) for name in purchase_orders)
+		self.assertEqual(first.supplier, "_Test Supplier")
+		self.assertEqual([d.item_code for d in first.items], item_codes[:2])
+		self.assertEqual(second.supplier, "_Test Supplier 1")
+		self.assertEqual([d.item_code for d in second.items], item_codes[2:])
+		self.assertEqual(second.items[0].qty, 4)
+		self.assertEqual(second.items[0].stock_qty, 4)
+
+	def test_make_purchase_orders_by_supplier_sets_schedule_date(self):
+		from erpnext.stock.doctype.material_request.material_request import make_purchase_orders_by_supplier
+
+		mr = make_material_request_for_items(["_Test Item"])
+		frappe.db.set_value("Material Request Item", mr.items[0].name, "schedule_date", add_days(today(), -1))
+
+		purchase_orders = make_purchase_orders_by_supplier(
+			mr.name,
+			[
+				{
+					"material_request_item": mr.items[0].name,
+					"item_code": "_Test Item",
+					"qty": 10,
+					"supplier": "_Test Supplier",
+				}
+			],
+		)
+
+		po = frappe.get_doc("Purchase Order", purchase_orders[0])
+		self.assertEqual(po.schedule_date, getdate(today()))
+
+		alerts = [m for m in frappe.get_message_log() if m.get("alert")]
+		self.assertTrue(any("was set to today" in m.get("message") for m in alerts))
+
+	def test_make_purchase_orders_by_supplier_invalid_rows(self):
+		from erpnext.stock.doctype.material_request.material_request import make_purchase_orders_by_supplier
+
+		mr = make_material_request_for_items(["_Test Item"])
+		row = {
+			"material_request_item": mr.items[0].name,
+			"item_code": "_Test Item",
+			"qty": 10,
+			"supplier": "_Test Supplier",
+		}
+
+		for invalid in [{"supplier": None}, {"qty": 0}, {"qty": -5}, {"qty": 11}]:
+			self.assertRaises(
+				frappe.ValidationError, make_purchase_orders_by_supplier, mr.name, [row | invalid]
+			)
+
+		self.assertRaises(frappe.ValidationError, make_purchase_orders_by_supplier, mr.name, [])
+
+		self.assertRaises(
+			frappe.ValidationError,
+			make_purchase_orders_by_supplier,
+			mr.name,
+			[row, row | {"supplier": "_Test Supplier 1"}],
+		)
+
+
+def create_item_with_default_supplier(item_code, supplier):
+	item = create_item(item_code)
+	item.set("item_defaults", [])
+	item.append(
+		"item_defaults",
+		{
+			"company": "_Test Company",
+			"default_warehouse": "_Test Warehouse - _TC",
+			"default_supplier": supplier,
+		},
+	)
+	item.save()
+
+	return item.name
+
+
+def make_material_request_for_items(item_codes, **args):
+	args = frappe._dict(args)
+	mr = frappe.new_doc("Material Request")
+	mr.material_request_type = args.material_request_type or "Purchase"
+	mr.company = args.company or "_Test Company"
+	mr.schedule_date = today()
+	for item_code in item_codes:
+		mr.append(
+			"items",
+			{
+				"item_code": item_code,
+				"qty": args.qty or 10,
+				"schedule_date": today(),
+				"warehouse": args.warehouse or "_Test Warehouse - _TC",
+			},
+		)
+
+	mr.insert()
+	mr.submit()
+
+	return mr
+
 
 def get_in_transit_warehouse(company):
 	if not frappe.db.exists("Warehouse Type", "Transit"):