diff --git a/erpnext/stock/doctype/material_request/mapper.py b/erpnext/stock/doctype/material_request/mapper.py
index 850b2ab9552..26db6143f69 100644
--- a/erpnext/stock/doctype/material_request/mapper.py
+++ b/erpnext/stock/doctype/material_request/mapper.py
@@ -207,6 +207,9 @@ def get_item_default_suppliers(source_name: str, filtered_children: str | list |
 def make_purchase_orders_by_supplier(source_name: str, item_suppliers: str | list) -> list[str]:
 	"""Create one draft Purchase Order per supplier for the given Material Request items."""
 	item_suppliers = frappe.parse_json(item_suppliers)
+	if not item_suppliers:
+		frappe.throw(_("Select at least one Item"))
+
 	pending_items = {
 		d["material_request_item"]: frappe._dict(d) for d in get_item_default_suppliers(source_name)
 	}
diff --git a/erpnext/stock/doctype/material_request/material_request.js b/erpnext/stock/doctype/material_request/material_request.js
index 42d672df36b..391fee9dbf2 100644
--- a/erpnext/stock/doctype/material_request/material_request.js
+++ b/erpnext/stock/doctype/material_request/material_request.js
@@ -439,7 +439,7 @@ frappe.ui.form.on("Material Request", {
 	},
 
 	select_suppliers_for_items: function (frm, items) {
-		const rows = items.map((item) => Object.assign({}, item, { qty: item.pending_qty }));
+		const rows = items.map((item) => Object.assign({}, item, { qty: item.pending_qty, __checked: 1 }));
 
 		const dialog = new frappe.ui.Dialog({
 			title: __("Select Supplier for Items"),
@@ -513,7 +513,10 @@ frappe.ui.form.on("Material Request", {
 			],
 			primary_action_label: __("Create"),
 			primary_action: function (values) {
-				const item_suppliers = values.items || [];
+				const item_suppliers = (values.items || []).filter((row) => row.__checked);
+				if (!item_suppliers.length) {
+					frappe.throw(__("Select at least one Item"));
+				}
 
 				const missing_supplier = item_suppliers.find((row) => !row.supplier);
 				if (missing_supplier) {